Effects of Dendroaspis Natriuretic Peptide on Calcium-Activated Potassium Current and Its Mechanism
نویسندگان
چکیده
منابع مشابه
Renal actions of synthetic dendroaspis natriuretic peptide.
BACKGROUND Dendroaspis natriuretic peptide (DNP), recently isolated from the venom of the green Mamba snake Dendroaspis angusticeps, is a 38 amino acid peptide containing a 17 amino acid disulfide ring structure similar to that of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). DNP-like immunoreactivity (DNP-LI) was reported to be present...
متن کاملCharacteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin-induced diabetic rats.
Dendroaspis natriuretic peptide (DNP) shares a functionally important sequence homology with other natriuretic peptides. However, the characteristics of DNP and its receptor in the context of diabetes remafin to be fully elucidated. In the present study, alterations in the plasma levels and tissue contents of DNP and the properties of its receptor in diabetic rats, induced by streptozotocin (ST...
متن کاملDendroaspis natriuretic peptide relaxes isolated human arteries and veins.
BACKGROUND Dendroaspis natriuretic peptide (DNP) is the newest member of the natriuretic peptide family and is a circulating peptide in humans. The effects of DNP on the human vasculature are unknown. Since other natriuretic peptides are known to cause vasorelaxation, we determined the response to DNP on human blood vessels in vitro. We also investigated the mechanism of DNP mediated vasorelaxa...
متن کاملA new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide.
AIM Dendroaspis natriuretic peptide (DNP) is the most recently identified member of the natriuretic peptide family. Although DNP has similar structure and function to other members, it is genetically different. The other members are known to cause vasorelaxation but the effects of DNP on vascular structure still remains unclear. In this study, we aimed to find out the role of DNP in the develop...
متن کاملTherapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure.
Dendroaspis natriuretic peptide (DNP), a recently discovered peptide, shares structural similarity to the other known natriuretic peptides, ANP, BNP, and CNP. Studies have reported that DNP is present in human and canine plasma and atrial myocardium and increased in plasma of humans with congestive heart failure (CHF). In addition, synthetic DNP is markedly natriuretic and diuretic and is a pot...
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ژورنال
عنوان ژورنال: The Journal of Physiological Sciences
سال: 2008
ISSN: 1880-6546,1880-6562
DOI: 10.2170/physiolsci.cr000108